Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2
Identifieur interne : 003781 ( Main/Exploration ); précédent : 003780; suivant : 003782Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2
Auteurs : Satoshi Orimo [Japon] ; Takeshi Amino [Japon] ; Masayuki Yokochi [Japon] ; Tohru Kojo [Japon] ; Toshiki Uchihara [Japon] ; Atsushi Takahashi [Japon] ; Koichi Wakabayashi [Japon] ; Hitoshi Takahashi [Japon] ; Nobutaka Hattori [Japon] ; Yoshikuni Mizuno [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 3-Iodobenzylguanidine (diagnostic use), 3-Iodobenzylguanidine (pharmacokinetics), Aged, Denervation, Ganglia, Sympathetic (metabolism), Ganglia, Sympathetic (physiopathology), Ganglia, Sympathetic (radionuclide imaging), Heart (innervation), Humans, MIBG myocardial scintigraphy, Male, Nervous system diseases, PARK2, Parkinson Disease (genetics), Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Radiopharmaceuticals (diagnostic use), Radiopharmaceuticals (pharmacokinetics), Scintigraphy, Sympathetic nerve, Tomography, Emission-Computed, Single-Photon, Ubiquitin-Protein Ligases (genetics), Uptake, cardiac sympathetic nerve, denervation.
- MESH :
- chemical , diagnostic use : 3-Iodobenzylguanidine, Radiopharmaceuticals.
- chemical , genetics : Ubiquitin-Protein Ligases.
- chemical , pharmacokinetics : 3-Iodobenzylguanidine, Radiopharmaceuticals.
- genetics : Parkinson Disease.
- innervation : Heart.
- metabolism : Ganglia, Sympathetic.
- physiopathology : Ganglia, Sympathetic, Parkinson Disease.
- radionuclide imaging : Ganglia, Sympathetic, Parkinson Disease.
- Aged, Humans, Male, Tomography, Emission-Computed, Single-Photon.
Abstract
We performed [123I] MIBG myocardial scintigraphy in two of three patients with PARK2 from unrelated families and examined the heart tissues from the three patients immunohistochemically using an antibody against tyrosine hydroxylase (TH) to see whether cardiac sympathetic nerve is involved. Cardiac uptake of MIBG was normal except for a slight decrease in the late phase in one of the patients. Postmortem examination revealed that TH‐immunoreactive nerve fibers in the epicardium were well preserved in all three patients. The present study confirmed that cardiac sympathetic nerve is well preserved in PARK2 with a homozygous exon deletion, which accounts for normal cardiac uptake of MIBG. Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa‐responsive Parkinsonism, as in PARK2. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20594
Affiliations:
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sortKey="Amino, Takeshi" sort="Amino, Takeshi" uniqKey="Amino T" first="Takeshi" last="Amino">Takeshi Amino</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kanto Central Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Yokochi, Masayuki" sort="Yokochi, Masayuki" uniqKey="Yokochi M" first="Masayuki" last="Yokochi">Masayuki Yokochi</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Ebara Metropolitan Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Kojo, Tohru" sort="Kojo, Tohru" uniqKey="Kojo T" first="Tohru" last="Kojo">Tohru Kojo</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Uchihara, Toshiki" sort="Uchihara, Toshiki" uniqKey="Uchihara T" first="Toshiki" last="Uchihara">Toshiki Uchihara</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Organ and Function Pathology Division, Yokufukai Geriatric Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Wakabayashi, Koichi" sort="Wakabayashi, Koichi" uniqKey="Wakabayashi K" first="Koichi" last="Wakabayashi">Koichi Wakabayashi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Hirosaki University School of Medicine, Hirosaki</wicri:regionArea><wicri:noRegion>Hirosaki</wicri:noRegion></affiliation></author><author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Brain Research Institute, University of Niigata, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Mizuno, Yoshikuni" sort="Mizuno, Yoshikuni" uniqKey="Mizuno Y" first="Yoshikuni" last="Mizuno">Yoshikuni Mizuno</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-10">2005-10</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1350">1350</biblScope><biblScope unit="page" to="1353">1353</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">93A1F555EE9922B77F75A14F22D7C2A6EE6E1916</idno><idno type="DOI">10.1002/mds.20594</idno><idno type="ArticleID">MDS20594</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3-Iodobenzylguanidine (diagnostic use)</term><term>3-Iodobenzylguanidine (pharmacokinetics)</term><term>Aged</term><term>Denervation</term><term>Ganglia, Sympathetic (metabolism)</term><term>Ganglia, Sympathetic (physiopathology)</term><term>Ganglia, Sympathetic (radionuclide imaging)</term><term>Heart (innervation)</term><term>Humans</term><term>MIBG myocardial scintigraphy</term><term>Male</term><term>Nervous system diseases</term><term>PARK2</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Radiopharmaceuticals (pharmacokinetics)</term><term>Scintigraphy</term><term>Sympathetic nerve</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Ubiquitin-Protein Ligases (genetics)</term><term>Uptake</term><term>cardiac sympathetic nerve</term><term>denervation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>3-Iodobenzylguanidine</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>3-Iodobenzylguanidine</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Heart</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Ganglia, Sympathetic</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Ganglia, Sympathetic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Ganglia, Sympathetic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Male</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Captation</term><term>Enervation</term><term>Nerf sympathique</term><term>Parkinson maladie</term><term>Scintigraphie</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed [123I] MIBG myocardial scintigraphy in two of three patients with PARK2 from unrelated families and examined the heart tissues from the three patients immunohistochemically using an antibody against tyrosine hydroxylase (TH) to see whether cardiac sympathetic nerve is involved. Cardiac uptake of MIBG was normal except for a slight decrease in the late phase in one of the patients. Postmortem examination revealed that TH‐immunoreactive nerve fibers in the epicardium were well preserved in all three patients. The present study confirmed that cardiac sympathetic nerve is well preserved in PARK2 with a homozygous exon deletion, which accounts for normal cardiac uptake of MIBG. Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa‐responsive Parkinsonism, as in PARK2. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Orimo, Satoshi" sort="Orimo, Satoshi" uniqKey="Orimo S" first="Satoshi" last="Orimo">Satoshi Orimo</name></noRegion><name sortKey="Amino, Takeshi" sort="Amino, Takeshi" uniqKey="Amino T" first="Takeshi" last="Amino">Takeshi Amino</name><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><name sortKey="Kojo, Tohru" sort="Kojo, Tohru" uniqKey="Kojo T" first="Tohru" last="Kojo">Tohru Kojo</name><name sortKey="Mizuno, Yoshikuni" sort="Mizuno, Yoshikuni" uniqKey="Mizuno Y" first="Yoshikuni" last="Mizuno">Yoshikuni Mizuno</name><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name><name sortKey="Uchihara, Toshiki" sort="Uchihara, Toshiki" uniqKey="Uchihara T" first="Toshiki" last="Uchihara">Toshiki Uchihara</name><name sortKey="Wakabayashi, Koichi" sort="Wakabayashi, Koichi" uniqKey="Wakabayashi K" first="Koichi" last="Wakabayashi">Koichi Wakabayashi</name><name sortKey="Yokochi, Masayuki" sort="Yokochi, Masayuki" uniqKey="Yokochi M" first="Masayuki" last="Yokochi">Masayuki Yokochi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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